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Posted On: 07/30/2025 7:23:49 PM
Post# of 155726
Garry Nolan's role with the CCR5 receptor.
Garry Nolan is the Rachford and Carlota A. Harris Professor in the Department of Pathology at the Stanford University School of Medicine.
He also holds a joint appointment in the Department of Microbiology and Immunology.
Why do we care?
In my original post, the entertaining YouTube interview of Nolan urges us to make him a Leronlimab ally.
https://www.youtube.com/watch?v=HxVVz2Jorzk
Gary Nolan, among his various research endeavors,
[ ] has contributed to our understanding of the CCR5 receptor, primarily in the context of its role as an HIV-1 co-receptor.
His research focused on
[ ] How the CCR5 receptor facilitates HIV-1 entry into cells.
[ ] Along with CD4, CCR5 is used by HIV-1 to enter cells like macrophages and T cells.
To investigate this mechanism, Nolan and his team studied
[ ] The role of CCR5's signal transduction.
[ ] The team introduced mutations in the cytoplasmic domains of CCR5,
[ ] including truncating the carboxyl-tail and mutating the DRY sequence.
[ ] These mutations blocked chemokine-dependent activation of second messengers like intracellular calcium fluxes and chemotaxis.
[ ] However, these mutations did not affect CCR5's function as an HIV-1 co-receptor.
[ ] This led to the conclusion that signal transduction, a typical function of G protein-coupled receptors like CCR5, is not necessary for CCR5 to act as an HIV-1 co-receptor.
In essence, Nolan's work demonstrated that
[ ] HIV can utilize CCR5 for entry even when the receptor's usual signaling functions are inhibited .
[ ] This finding is significant for understanding HIV-1 entry and may contribute to developing new therapies.
Garry Nolan is the Rachford and Carlota A. Harris Professor in the Department of Pathology at the Stanford University School of Medicine.
He also holds a joint appointment in the Department of Microbiology and Immunology.
Why do we care?
In my original post, the entertaining YouTube interview of Nolan urges us to make him a Leronlimab ally.
https://www.youtube.com/watch?v=HxVVz2Jorzk
Gary Nolan, among his various research endeavors,
[ ] has contributed to our understanding of the CCR5 receptor, primarily in the context of its role as an HIV-1 co-receptor.
His research focused on
[ ] How the CCR5 receptor facilitates HIV-1 entry into cells.
[ ] Along with CD4, CCR5 is used by HIV-1 to enter cells like macrophages and T cells.
To investigate this mechanism, Nolan and his team studied
[ ] The role of CCR5's signal transduction.
[ ] The team introduced mutations in the cytoplasmic domains of CCR5,
[ ] including truncating the carboxyl-tail and mutating the DRY sequence.
[ ] These mutations blocked chemokine-dependent activation of second messengers like intracellular calcium fluxes and chemotaxis.
[ ] However, these mutations did not affect CCR5's function as an HIV-1 co-receptor.
[ ] This led to the conclusion that signal transduction, a typical function of G protein-coupled receptors like CCR5, is not necessary for CCR5 to act as an HIV-1 co-receptor.
In essence, Nolan's work demonstrated that
[ ] HIV can utilize CCR5 for entry even when the receptor's usual signaling functions are inhibited .
[ ] This finding is significant for understanding HIV-1 entry and may contribute to developing new therapies.
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