Quote:

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"This is an exciting study because it suggests that inhibiting this cGAS-STING pathway could make the brain more resistant to the Alzheimer’s process, even in the face of significant tau accumulation."

Although not mentioned in the article, I believe this pathway triggers the production of CCL5 amongst other cytokines.

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cGas-Sting increases both CCL5 and CCR5 leading to impaired clearance of beta-amyloid and tau plaques. More importantly the increase in CCR5 and CCL5 leads to an upregulation of overactive microglia that kills neurons.