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Posted On: 07/23/2025 3:07:08 PM
Post# of 155717
Wiki even makes a separate section for warning about serious side effects...if we'd had that kind of profile, I imagine our hold would never have been lifted...and here we sit, effective and SAFE...(ohm, if you read this -- would a checkpoint inhibitor paired with LL have the same risk of colitis?)
"A major drawback of ipilimumab therapy is its association with severe and potentially fatal immunological adverse effects due to T cell activation and proliferation, occurring in 10% to 20% of patients.[33] Serious adverse effects include stomach pain, bloating, constipation, diarrhea, fever, trouble breathing, and urinating problems. A "risk evaluation and mitigation strategy" informs prescribers of the potential risks.[21][34]
Between 5.7 and 9.1% of individuals treated with ipilimumab develop checkpoint inhibitor induced colitis.[35]
Individual cases of severe neurologic disorders following ipilimumab have been observed, including acute inflammatory demyelination polyneuropathy and an ascending motor paralysis, and myasthenia gravis.[36] "
"A major drawback of ipilimumab therapy is its association with severe and potentially fatal immunological adverse effects due to T cell activation and proliferation, occurring in 10% to 20% of patients.[33] Serious adverse effects include stomach pain, bloating, constipation, diarrhea, fever, trouble breathing, and urinating problems. A "risk evaluation and mitigation strategy" informs prescribers of the potential risks.[21][34]
Between 5.7 and 9.1% of individuals treated with ipilimumab develop checkpoint inhibitor induced colitis.[35]
Individual cases of severe neurologic disorders following ipilimumab have been observed, including acute inflammatory demyelination polyneuropathy and an ascending motor paralysis, and myasthenia gravis.[36] "
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