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The chemo causes indiscriminate DNA damage across all cell types be cancer or healthy cells and that’s why the body needs a break to repair the DNA. If I’m thinking right and I think you might’ve mentioned this before the expression of PDL one on cancer cells allow them to be more effectively. Targeted by chemotherapy and healthy cells are not affected nearly as much by the chemo. Do I have that right? And DNA repair happens much faster and healthy cells after being given LL. I assume this would be the same for BPG drug correct?

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Chemotherapy will damage healthy cells and tumor cells. Newer chemotherapy uses markers that are expressed on tumor cells to target just the tumor with much less damage to normal cells. PD-L1 would probably not be optimal for targeted chemotherapy because of expression of PD-L1 on normal cells. PD-L1 is targeted by anti-PD-L1 ICIs not chemotherapy. DNA repair doesn't happen much faster with leronlimab. If that was the case then tumor cells would survive.

Leronlimab stops the tumor cell DNA from repairing via PI3K/AKT/ELF4E inhibition causing tumor cells to die. The BPG drug does not affect DNA repair directly.