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Posted On: 07/13/2025 1:42:49 PM
Post# of 155721
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What role does CXCR4 play in this?
CXCR4 HIV transfer from human to human is extremely rare and is usually seen in breastfeeding mothers transferring it to infants. With CCR5 being very abundant compared to CXCR4 and when no treatment is present any mutated CXCR4 variants are overwhelmed by CCR5 binding HIV. CXCR4 almost always develops when HIV antiviral therapies are used. With less competition from CCR5 HIV then CXCR4 HIV can flourish. Of note: CCR5 blockers decrease expression of CXCR4 unlike ART therapies.
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What are cancer rates and rates of other CCR5 positive disease states (OHM’s List) between single phenotype, double phenotype and non-delta32 “patients “. That question is going to take a while.
I realized a long time ago that blocking CCR5 and CCR5 Delta 32 deletions will not have the exact same responses except when it comes to something like HIV where a virus binds directly to CCR5.
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