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Posted On: 07/06/2025 8:43:11 PM
Post# of 155049
To Any/All who feel like answering:
Let's move to the point when the patient has been treated for a few months and his tumor burden has fallen substantially. It is about that time when PD-L1 has increased on the surfaces of CTCs and CTC quantity also has increased.
At this point, we can understand, that the Tumor has converted from being Cold to Being Hot.
First question is, when the tumor converts, is it still putting out RANTES? since it no longer depends on RANTES suppressive effects since the PD-1 pathway is keeping it alive?
If it is still emitting RANTES, and LL is on board still, I don't see the point of why the tumor would be doing that since there are no CCR5 receptors to bind to if LL is on board.
If it is not emitting RANTES, then there would be no problem in stopping LL administration once tumor goes Hot.
Question is, if LL is stopped, does the Tumor recognize the absence of LL and again resume to emitting RANTES in order to suppress the T Cells and also protect itself via PD-1?
Or once the tumor goes Hot, does it forsake RANTES communication entirely?
Last question, does it make most sense to maintain LL administration even while the Tumor has become Hot in order to protect against any RANTES resurgence?
Let's move to the point when the patient has been treated for a few months and his tumor burden has fallen substantially. It is about that time when PD-L1 has increased on the surfaces of CTCs and CTC quantity also has increased.
At this point, we can understand, that the Tumor has converted from being Cold to Being Hot.
First question is, when the tumor converts, is it still putting out RANTES? since it no longer depends on RANTES suppressive effects since the PD-1 pathway is keeping it alive?
If it is still emitting RANTES, and LL is on board still, I don't see the point of why the tumor would be doing that since there are no CCR5 receptors to bind to if LL is on board.
If it is not emitting RANTES, then there would be no problem in stopping LL administration once tumor goes Hot.
Question is, if LL is stopped, does the Tumor recognize the absence of LL and again resume to emitting RANTES in order to suppress the T Cells and also protect itself via PD-1?
Or once the tumor goes Hot, does it forsake RANTES communication entirely?
Last question, does it make most sense to maintain LL administration even while the Tumor has become Hot in order to protect against any RANTES resurgence?
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