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Posted On: 06/19/2025 2:14:08 AM
Post# of 154582
Quote:
The term "canonical immune checkpoint" most often refers to the PD-1/PD-L1 pathway and the CTLA-4 pathway, which are the most well-studied and targeted immune checkpoint pathways in cancer immunotherapy.
On the regulator list. - CTLA-4 (via IFN-a downreg)[-]
It is possible that like PD-L1 it may increase for that 60 day window due to the initial onslaught of killer T-cells.
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