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Posted On: 06/02/2025 3:56:59 PM
Post# of 153915
Overall Survival and Quality-of-Life Superiority in Modern Phase 3 Oncology Trials
Let's get our trials run.
https://jamanetwork.com/journals/jamaoncology...le/2834980
Quote:
In this meta-epidemiological study, across 791 trials, 53% of trials were interpreted as showing primary end-point superiority; however, overall survival and quality-of-life superiority were shown in just 28% and 11% of trials, respectively. In 32% of trials, superiority of either overall survival or quality of life was demonstrated; in 6%, both were shown.
Meaning: Although phase 3 trials are often interpreted as demonstrating superiority, overall survival and quality of life, which may be the most relevant end points to patients, are uncommonly improved.
Let's get our trials run.
https://jamanetwork.com/journals/jamaoncology...le/2834980
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