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Posted On: 05/24/2025 9:27:26 AM
Post# of 154678
I think, in only a few words, you extract the precise reason why PD-L1 is upregulated in from 30-90 days after leronlimab is started.
It might not be the signaling to the tumor cell per se, but rather, the actual attack of, or the actual destruction of the tumor cells which induces the upregulation of PD-L1 on their cell surface.
If it had to do with signaling, then LL might have another MOA, but I tend to think that it is the actual attack and subsequent destruction which is actually the cause of the upregulation.
Regardless, this tendency for LL to induce this upregulation of PD-L1 is profound and proof positive it has yet another anti-tumor effect which can not be denied.
Quote:
MSI tumors are more often hot because the mismatch repair of DNA will signal to the immune system to destroy tumor cells.
It might not be the signaling to the tumor cell per se, but rather, the actual attack of, or the actual destruction of the tumor cells which induces the upregulation of PD-L1 on their cell surface.
If it had to do with signaling, then LL might have another MOA, but I tend to think that it is the actual attack and subsequent destruction which is actually the cause of the upregulation.
Regardless, this tendency for LL to induce this upregulation of PD-L1 is profound and proof positive it has yet another anti-tumor effect which can not be denied.
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