(Total Views: 682)
Posted On: 05/15/2025 8:36:41 PM
Post# of 154857
Let's not forget that many of these patients went through 3 or 4 lines of treatment before they got to try Leronlimab. I'm reminded of the Einstein covid patients that were the worst of the worst, including transplant patients. And while only a few lived, every one of them showed an immune response from LL. Sadly some had too much to overcome, and I think it's very likely a strong handful of these breast cancer patients were in a similar boat. At some point you're going to have a difficult time reversing cancer, and maybe some of these patients had a very small window that 350 couldn't overcome, but 700 could have. Or neither were going to work due to progression of the disease, or a unique metabolic makeup that just simply wouldn't respond.
I'm super excited about the survival data and am looking forward to the crc trial filling, the next step in mTNBC, a (very likely) partner getting on board to infuse cash and awareness, and also glio. I think the second attempt at glio was likely informed heavily by the survival and moa analysis that was shaking out as they set about giving glio a second look. I'm hopefuly that they are able to show a through-line across crc/basket, mTNBC, and glio because if they can show any substantial effect in glio there's always a chance of the coveted emergency approval. I would love some sort of accelerated approval of LL for mTNBC, but there are a lot of treatments already that have some effect, even if it isn't as good as what we now believe LL can do when paired with an ICI. But with glio there aren't many options and the disease hits fast and hard. Let's all cross our fingers AND DOUBLE EVERY ELEVEN that this glio redo is outstanding. It'll help build Cytodyn's worth for partnerships and buyouts, but more importantly it could end up meaning extended life for some of the most brutal cancers a person can be diagnosed with.
Lastly, I think it's important I reiterate that you should ALWAYS double eleven. Always. Trust me. I was once approached by Stuey Ungar, who was probably the best poker player who ever lived. He fought demons and lived a much shorter life than he should have, otherwise he'd be a household name. But while he was alive we got to know each other in Biloxi while fleecing locals in secret underground games. He saw the spark in my eye and the quality of my play, deciding it was smarter to pair up and teach me his ways lest I overtake him, leaving him floundering in my wake with nothing.
So he taught me about probability, and how I can use things like VPIP to my advantage, shaping my game to where I was unstoppable. We hit Vegas and I was crushing everything from the Omaha Hi-Lo NL to Razz and everything in between. I got banned from many casinos, but not for my play. They were concerned I was too handsome and distracting the cocktail waitresses. I, of course, was tipping liberally on every bottle of Opus One I ordered (daily drinker back then) and they were hovering over me like dancers at an otherwise empty strip club.
But I flew a little too close to the sun and had to switch to blackjack for reasons I won't go into. But the last thing Stu said to me was, "Always double your elevens. Always." This was shortly after his unexpected comeback win at the World Series of Poker in 1997. Years later I was gifted his book before it was published because I was a prolific poker writer, the publisher hilariously unaware that he was my mentor. It was an amazing read, but heartbreaking too. But then I noticed that if you took the first letter of each chapter and laid them out, it spelled "DOUBLE YOUR ELEVENS" and I nodded to the heavens. Message received, pal. Message received.
I'm super excited about the survival data and am looking forward to the crc trial filling, the next step in mTNBC, a (very likely) partner getting on board to infuse cash and awareness, and also glio. I think the second attempt at glio was likely informed heavily by the survival and moa analysis that was shaking out as they set about giving glio a second look. I'm hopefuly that they are able to show a through-line across crc/basket, mTNBC, and glio because if they can show any substantial effect in glio there's always a chance of the coveted emergency approval. I would love some sort of accelerated approval of LL for mTNBC, but there are a lot of treatments already that have some effect, even if it isn't as good as what we now believe LL can do when paired with an ICI. But with glio there aren't many options and the disease hits fast and hard. Let's all cross our fingers AND DOUBLE EVERY ELEVEN that this glio redo is outstanding. It'll help build Cytodyn's worth for partnerships and buyouts, but more importantly it could end up meaning extended life for some of the most brutal cancers a person can be diagnosed with.
Lastly, I think it's important I reiterate that you should ALWAYS double eleven. Always. Trust me. I was once approached by Stuey Ungar, who was probably the best poker player who ever lived. He fought demons and lived a much shorter life than he should have, otherwise he'd be a household name. But while he was alive we got to know each other in Biloxi while fleecing locals in secret underground games. He saw the spark in my eye and the quality of my play, deciding it was smarter to pair up and teach me his ways lest I overtake him, leaving him floundering in my wake with nothing.
So he taught me about probability, and how I can use things like VPIP to my advantage, shaping my game to where I was unstoppable. We hit Vegas and I was crushing everything from the Omaha Hi-Lo NL to Razz and everything in between. I got banned from many casinos, but not for my play. They were concerned I was too handsome and distracting the cocktail waitresses. I, of course, was tipping liberally on every bottle of Opus One I ordered (daily drinker back then) and they were hovering over me like dancers at an otherwise empty strip club.
But I flew a little too close to the sun and had to switch to blackjack for reasons I won't go into. But the last thing Stu said to me was, "Always double your elevens. Always." This was shortly after his unexpected comeback win at the World Series of Poker in 1997. Years later I was gifted his book before it was published because I was a prolific poker writer, the publisher hilariously unaware that he was my mentor. It was an amazing read, but heartbreaking too. But then I noticed that if you took the first letter of each chapter and laid them out, it spelled "DOUBLE YOUR ELEVENS" and I nodded to the heavens. Message received, pal. Message received.
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