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Posted On: 05/13/2025 1:34:07 PM
Post# of 153174

Re: KenChowder #152774
Quote:
My takeaway from the PR is this, and it is no small matter:
Quote:
The Company confirmed that 5/5 patients (100%) who demonstrated a significant increase in PD-L1 expression after receiving leronlimab and received treatment with any ICI remain alive today. Four of these patients (80%) currently identify as having no evidence of disease, and the fifth patient is alive and identified by the clinical site as “stable.”
EVERY patient who had a significant increase in PD-L1 expression after receiving Leron is alive today.
66.6% aren't. What we need to know is how many of those 66.6% were also using PD-1 inhibitors. If it was only those 5 or there were only a couple of the 66.6% that were then it would trend towards a leronlimab/ PD-1 inhibitor combo being a winner. It may be something as simple as every one of the 17 being on 525mg or 700mg and those 5 having less disease severity or genetics that respond better to leronlimab. That's why I like to have data it's the only way to parse out what's going on.


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