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Posted On: 03/19/2025 9:13:05 PM
Post# of 151484

I don’t believe it has been noted here that the last letter strongly suggests that our new preclinical LL+ temozolomide follow-up to the disappointing lleronlimab-only GBM study has been yielding positive results.
Back in December Dr. Lalezari wrote:
From the last letter:
To me, “currently available” suggests that the study, presently about three months long, is still on!
Back in December Dr. Lalezari wrote:
Quote:.
Lastly, the Company remains focused on the possible use of leronlimab in the treatment of GBM. Preliminary results from a preclinical study performed at the Albert Einstein College of Medicine do not appear to show a difference in outcome with leronlimab compared to the control arm. The Company has committed to repeating the study based on unpublished observations by Dr. Pestell’s lab and will now employ a treatment sequence involving temozolomide and leronlimab. This follow-up study will start immediately and should help clarify the potential therapeutic benefit of leronlimab in the treatment of GBM. CytoDyn is also currently in discussions with a key opinion leader in neuro-oncology about the possibility of initiating a pilot study in patients with GBM based on Dr. Pestell’s unpublished work and the outcome of the follow-up preclinical study
From the last letter:
Quote:
The Company also continues to explore the possible use of leronlimab in the treatment of glioblastoma multiforme (“GBM”). A preclinical study at the Albert Einstein College of Medicine sequencing temozolomide and leronlimab is now underway. CytoDyn is also in discussions with several KOLs in neuro-oncology about the possibility of initiating a pilot study in patients with GBM, also based on currently available data.
To me, “currently available” suggests that the study, presently about three months long, is still on!


Whatever happens, we have got
Le-Ron-Li-Mab, and they have not.
Le-Ron-Li-Mab, and they have not.
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