(Total Views: 590)
Posted On: 02/24/2025 9:48:23 PM
Post# of 154852
Quote:
Way out of my league but fascinating. Didn't see mention of CCR5...(and could be way off base) but seems like these findings might compliment leronlimab's MOA: stopping metastasis. ???
Our observations suggest that matrix organization, cytoskeletal features and transcriptional activation are strong predictors of aggressive behavior of cancer cells. Patients with these tumour architectures could benefit from therapies targeting these pro-invasive and pro-survival programs linked to collagen dynamics.
https://www.nature.com/articles/s41467-025-56299-7
Leronlimab downregulates excessive collagen and a number of MMPs (matrix metalloproteinases) so it would indeed help. Collagen and MMPs are also implicated in neurological, liver, kidney, heart and a number of other diseases.
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