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Posted On: 02/19/2025 10:49:32 AM
Post# of 154852
Addition information on this.
From Google AI:
"M2 macrophages, also known as tumor-associated macrophages (TAMs), are a type of macrophage that promote the growth and spread of cancer. They do this by suppressing the immune system, promoting angiogenesis, and supporting tumor cell proliferation.
How M2 macrophages promote cancer
Angiogenesis: M2 macrophages secrete VEGF, which promotes angiogenesis in tumors.
Immune suppression: M2 macrophages inhibit NK cell function by secreting inhibitory factors and through cell-cell contact.
Tumor cell proliferation: M2 macrophages promote cancer cell proliferation and invasion.
Metastasis: M2 macrophages facilitate metastasis.
Targeting M2 macrophages
Decoy oligodeoxynucleotides: Decoy ODNs can inhibit M2-like polarization and control tumor growth.
Blocking CSF-1/CSF-1 receptor and CCL2/CCR2 pathways: These pathways can be blocked to restrict the infiltration of TAMs.
Regulating TAM repolarization: Strategies can be developed to regulate TAM repolarization.
M2 macrophages and prognosis
A high proportion of M2-like macrophages in TAMs is associated with poor prognosis and shorter survival in many cancers.
Research on M2 macrophages
Research on M2 macrophages is ongoing to develop new therapeutic strategies to improve outcomes for cancer patients."
Leronlimab blocks CSF-1 receptor and CCL2/CCR2 pathways by blocking the CCR5 receptors. Additionally, blocking the CCR5 receptors reprograms the M2 macrophages (that the cancer had programmed) back to M1 macrophages, which will attack tumor cells and circulating tumor cells and help stop angiogenesis (redirected blood supply) to the cancer cells.
I'm sure Ohm20 can break it down even further.
From Google AI:
"M2 macrophages, also known as tumor-associated macrophages (TAMs), are a type of macrophage that promote the growth and spread of cancer. They do this by suppressing the immune system, promoting angiogenesis, and supporting tumor cell proliferation.
How M2 macrophages promote cancer
Angiogenesis: M2 macrophages secrete VEGF, which promotes angiogenesis in tumors.
Immune suppression: M2 macrophages inhibit NK cell function by secreting inhibitory factors and through cell-cell contact.
Tumor cell proliferation: M2 macrophages promote cancer cell proliferation and invasion.
Metastasis: M2 macrophages facilitate metastasis.
Targeting M2 macrophages
Decoy oligodeoxynucleotides: Decoy ODNs can inhibit M2-like polarization and control tumor growth.
Blocking CSF-1/CSF-1 receptor and CCL2/CCR2 pathways: These pathways can be blocked to restrict the infiltration of TAMs.
Regulating TAM repolarization: Strategies can be developed to regulate TAM repolarization.
M2 macrophages and prognosis
A high proportion of M2-like macrophages in TAMs is associated with poor prognosis and shorter survival in many cancers.
Research on M2 macrophages
Research on M2 macrophages is ongoing to develop new therapeutic strategies to improve outcomes for cancer patients."
Leronlimab blocks CSF-1 receptor and CCL2/CCR2 pathways by blocking the CCR5 receptors. Additionally, blocking the CCR5 receptors reprograms the M2 macrophages (that the cancer had programmed) back to M1 macrophages, which will attack tumor cells and circulating tumor cells and help stop angiogenesis (redirected blood supply) to the cancer cells.
I'm sure Ohm20 can break it down even further.
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