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Posted On: 02/05/2025 12:41:09 AM
Post# of 149930
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Re: HouseofCards #149841
Quote:
I thought I remembered reading that we showed decent results in GBM in our basket trial so I'm really curious why the mouse study didn't show positive results.
It may be something as simple as the mouse brain blood barrier is less leaky under inflammatory conditions and so less leronlimab gets through. Mice have a much more challenging environment when it comes to infective agents so it would make sense that their blood brain barrier would have to have tighter junctions under insult.
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