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Bockorny said the combination showcased a manageable toxicity profile. The rate of grade 3/4 treatment-related adverse effects (TRAEs) was 41%, most of which was attributable to grade 3 immune-mediated diarrhea/colitis (21%).

Other TRAEs reported with the combination included nausea (all-grade, 33%; grade 3, 4%), vomiting (all-grade, 17%), fatigue (all-grade, 38%; grade 3, 4%), pyrexia (all-grade, 25%), rash (all-grade, 33%; grade 3, 4%), pruritus (all-grade, 33%), and arthralgia (all-grade, 21%).

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