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Posted On: 12/08/2024 1:31:51 PM
Post# of 148863
Got a question pertaining to reservoirs and HIV Cure.
So we know that the recent discovery Jonah Sacha made using bNAbs, ART and leronlimab led to the non-development of any reservoirs of HIV despite HIV inoculation. It also led to the eradication of HIV for 1.25 years following inoculation.
My question is regarding LATCH. The patients slated for this protocol would have failed ART and so have developed a significant reservoir of HIV. Would a stem cell transplant eradicate the reservoir in the recipient patient?
How would the same be achieved using AAV?
So we know that the recent discovery Jonah Sacha made using bNAbs, ART and leronlimab led to the non-development of any reservoirs of HIV despite HIV inoculation. It also led to the eradication of HIV for 1.25 years following inoculation.
My question is regarding LATCH. The patients slated for this protocol would have failed ART and so have developed a significant reservoir of HIV. Would a stem cell transplant eradicate the reservoir in the recipient patient?
How would the same be achieved using AAV?
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