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Are you suggesting Leronlimab has an inflammatory effect due to Macrophage shift?

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Here is the beauty of leronlimab. It does produce a shift to M1 (inflammatory) type macrophages/microglia and increase the CD4 and CD8 versions when they've been devastated by infections. Those macrophages and microglia are necessary to fighting off bacterial and viral infections, removal of dead cells and killing off of aberrant cells such as those in cancer. But leronlimab also reduces production of inflammatory cytokines by blocking the binding of CCL ligands which then don't activate via CCR5. In a overactive inflammatory state leronlimab tones down that over-reactivity but the increased expression of the other CCR receptors that bind the same ligands as CCR5 means that you will still have a strong immune response. Without that M2 to M1 macrophage switch and the rebound of CD4 and CD8 macrophages/microglia you would have a weakened immune system.