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Posted On: 11/08/2024 6:36:11 PM
Post# of 148863
Our Dr. Otto Yang profile:
He then pursued fellowship at Massachusetts General Hospital, where he developed a research program studying the role of CD8+ T lymphocytes (CTL, which are killer T cells that can destroy cells infected with viruses or which are malignant) in HIV-1 pathogenesis. A more recent research interest has been the role of CTL in the development of rejection in organ transplant patients. Dr. Yang has begun working with the new composite tissue transplantation program at UCLA, which will perform hand and face transplants, studying the role of this arm of immunity in causing tissue rejection.
https://www.cytodyn.com/our-team/scientific-advisory-board
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Some Ai:
What is the function of the CD8 T cell?
CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire effector functions, enabling them to eliminate infected or malignant cells.
Nov 1, 2023
CD8+ T cells are able to release their granules, kill an infected cell, then move to a new target and kill again, often referred to as serial killing.
___
Immune system:
CCR5 helps regulate the immune system by directing immune cells to inflammation sites. It also regulates the trafficking and functions of T lymphocytes, macrophages, and dendritic cells.
___
Excerpts from Massachusetts General programs:
* Finally, vascular tissue allografts such as hand and face transplants have eased the suffering of burn patients and injured soldiers."
& this:
* However, 20 patients die every day in the U.S. awaiting an organ transplant, while scores of transplanted patients die yearly because of chronic rejection and the side effects of chronic immunosuppression.
Better understanding of transplantation biology is critical to developing new ways to prevent rejection, to eliminating the need for chronic immunosuppression and to finding alternative sources of organs, tissues and cells for the thousands of patients who die each year waiting for a transplant."
https://www.massgeneral.org/transplant/cts/about
___
Ai:
Chronic immunosuppression is a drug regimen that patients take after an organ transplant to prevent their immune system from attacking the new organ. It's necessary to keep the transplanted organ healthy, and patients must take these medications for life.
Chronic immunosuppression works by:
Inhibiting the formation of immune precursor cells, Destroying immunocompetent cells, and Suppressing antibody producing B- and T-lymphocytes.
While chronic immunosuppression is essential for the success of an organ transplant, it can have complications.
These include:
Increased risk of malignancy
Immunosuppressants don't target the immune response to the transplanted organ, so they can also affect other protective immune system functions.
This can increase the risk of certain cancers, especially nonmelanomatous skin cancers and gastrointestinal (GI) cancers.
Decreased ability to neutralize malignantly transformed cells
Immunosuppressants can make it harder for the body to neutralize cells that have been transformed by a virus or other cause.
___
The above reminds of the Long Acting Leronlimab bone marrow & tissue studies.
To this non medical person, looks that Dr. Yang is also working on potentially groundbreaking applications for additional LL combination treatments.
Including possibly related to organ donations.
He then pursued fellowship at Massachusetts General Hospital, where he developed a research program studying the role of CD8+ T lymphocytes (CTL, which are killer T cells that can destroy cells infected with viruses or which are malignant) in HIV-1 pathogenesis. A more recent research interest has been the role of CTL in the development of rejection in organ transplant patients. Dr. Yang has begun working with the new composite tissue transplantation program at UCLA, which will perform hand and face transplants, studying the role of this arm of immunity in causing tissue rejection.
https://www.cytodyn.com/our-team/scientific-advisory-board
___
Some Ai:
What is the function of the CD8 T cell?
CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire effector functions, enabling them to eliminate infected or malignant cells.
Nov 1, 2023
CD8+ T cells are able to release their granules, kill an infected cell, then move to a new target and kill again, often referred to as serial killing.
___
Immune system:
CCR5 helps regulate the immune system by directing immune cells to inflammation sites. It also regulates the trafficking and functions of T lymphocytes, macrophages, and dendritic cells.
___
Excerpts from Massachusetts General programs:
* Finally, vascular tissue allografts such as hand and face transplants have eased the suffering of burn patients and injured soldiers."
& this:
* However, 20 patients die every day in the U.S. awaiting an organ transplant, while scores of transplanted patients die yearly because of chronic rejection and the side effects of chronic immunosuppression.
Better understanding of transplantation biology is critical to developing new ways to prevent rejection, to eliminating the need for chronic immunosuppression and to finding alternative sources of organs, tissues and cells for the thousands of patients who die each year waiting for a transplant."
https://www.massgeneral.org/transplant/cts/about
___
Ai:
Chronic immunosuppression is a drug regimen that patients take after an organ transplant to prevent their immune system from attacking the new organ. It's necessary to keep the transplanted organ healthy, and patients must take these medications for life.
Chronic immunosuppression works by:
Inhibiting the formation of immune precursor cells, Destroying immunocompetent cells, and Suppressing antibody producing B- and T-lymphocytes.
While chronic immunosuppression is essential for the success of an organ transplant, it can have complications.
These include:
Increased risk of malignancy
Immunosuppressants don't target the immune response to the transplanted organ, so they can also affect other protective immune system functions.
This can increase the risk of certain cancers, especially nonmelanomatous skin cancers and gastrointestinal (GI) cancers.
Decreased ability to neutralize malignantly transformed cells
Immunosuppressants can make it harder for the body to neutralize cells that have been transformed by a virus or other cause.
___
The above reminds of the Long Acting Leronlimab bone marrow & tissue studies.
To this non medical person, looks that Dr. Yang is also working on potentially groundbreaking applications for additional LL combination treatments.
Including possibly related to organ donations.
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