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Posted On: 10/19/2024 8:58:03 PM
Post# of 148870
This is what I asked the Magic 8 ball:
So my question to any/all who might know, when CCR5 is bound by leronlimab and is then subsequently internalized by the cell, does the cell actually pull in the large monoclonal antibody inside the cell? If so, does the ll molecule get metabolized there and then or does it remain intact and then shuttled back out of the cell.
How does the cell separate LL from the CCR5 receptor since the affinity is so strong between LL and CCR5?
Does the cell only internalize CCR5 while leaving LL still outside?
If the cell internalizes CCR5 and after a while pushes CCR5 back out to the surface, what happened to the ll molecule that was bound to it?
Quote:
"is the CCR5 ligand always internalized once it has been bound to by a ligand, or are there times when it is not internalized into the cell?
ChatGPT said:
ChatGPT
The internalization of the CCR5 receptor after ligand binding is not always guaranteed; it can depend on several factors, including:
Ligand Type: Different ligands (e.g., CCL5 vs. CCL2) can induce varying levels of receptor internalization. Some ligands may promote strong internalization, while others may lead to partial or minimal internalization.
Receptor State: The phosphorylation status of the CCR5 receptor after ligand binding can influence whether it is internalized. Phosphorylation typically promotes internalization, but if the receptor does not undergo sufficient phosphorylation, it may not be internalized.
Cell Type: Different cell types can have varying mechanisms and efficiencies for receptor internalization, influencing how they respond to ligand binding.
Concentration of Ligand: High concentrations of ligands can lead to more robust internalization, while lower concentrations might result in reduced internalization.
Cellular Context: The presence of other signaling molecules or the state of the cell (e.g., activated vs. resting) can also affect internalization.
In summary, while ligand binding to CCR5 often leads to internalization, it is not an absolute rule and can vary based on multiple factors."
So my question to any/all who might know, when CCR5 is bound by leronlimab and is then subsequently internalized by the cell, does the cell actually pull in the large monoclonal antibody inside the cell? If so, does the ll molecule get metabolized there and then or does it remain intact and then shuttled back out of the cell.
How does the cell separate LL from the CCR5 receptor since the affinity is so strong between LL and CCR5?
Does the cell only internalize CCR5 while leaving LL still outside?
If the cell internalizes CCR5 and after a while pushes CCR5 back out to the surface, what happened to the ll molecule that was bound to it?
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