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Posted On: 10/05/2024 10:39:36 PM
Post# of 154140
*Citation43
However, the administration of a highly potent antiviral human mAb cocktail to Zika virus-infected pregnant macaques, at the time of peak viremia, was insufficient to block viral replication in the fetal compartment"
*The heightened mAb levels identified in dams and newborns in this study could translate to protection against HIV viral challenges for dams and neonates.
*While our study did not directly test protection against viral challenges, CCR5 blockade by leronlimab does not necessitate additional effector or immune components from the host.
*Ultimately, however, we will evaluate the protection of newborns against viral infection afforded by the in-utero leronlimab-PLS transfer in our follow-up study to confirm treatment efficacy.
___
Functionally controling diseases @ fetus.
No higher calling than that.
Godspeed.
However, the administration of a highly potent antiviral human mAb cocktail to Zika virus-infected pregnant macaques, at the time of peak viremia, was insufficient to block viral replication in the fetal compartment"
*The heightened mAb levels identified in dams and newborns in this study could translate to protection against HIV viral challenges for dams and neonates.
*While our study did not directly test protection against viral challenges, CCR5 blockade by leronlimab does not necessitate additional effector or immune components from the host.
*Ultimately, however, we will evaluate the protection of newborns against viral infection afforded by the in-utero leronlimab-PLS transfer in our follow-up study to confirm treatment efficacy.
___
Functionally controling diseases @ fetus.
No higher calling than that.
Godspeed.
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