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Posted On: 09/24/2024 10:45:57 AM
Post# of 154343
Hi Hoops,
not sure which three studies you are talking about, but it sounds like there was at least one and maybe two studies in this group that were at 350 mg. Dr Jay:
Ohm can correct me here, but I think it's only at the 700 mg dose that Leron achieves 100% occupancy of the CCR5 chemokine receptor. I think you can extrapolate that 700 mg would generally be more effective.
not sure which three studies you are talking about, but it sounds like there was at least one and maybe two studies in this group that were at 350 mg. Dr Jay:
Quote:
We have contracted with the lab to perform a pre-clinical mouse study, evaluating both 350 and 700, milligram dose levels alone, and in combination with Resmetirom, a drug recently approved by the FDA for the treatment of mash.
Ohm can correct me here, but I think it's only at the 700 mg dose that Leron achieves 100% occupancy of the CCR5 chemokine receptor. I think you can extrapolate that 700 mg would generally be more effective.
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