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Posted On: 09/23/2024 4:31:02 AM
Post# of 154728
More on superkines - engineered cytokines
With a deeper understanding of the structural principles and functional signals of cytokine-receptor interactions, artificial modification of cytokine signaling through protein engineering and synthetic immunology has become an increasingly feasible and powerful approach. Engineered cytokines are designed to selectively target cells. Herein, the theoretical and experimental evidence of cytokine engineering is reviewed, and the “supercytokines” resulting from structural enhancement and the “immunocytokines” generated by antibody fusion are described. Finally, the “engager cytokines” formed by the crosslinking of cytokines and bispecific immune engagers and other synthetic cytokines formed by nonnatural analogs are also discussed.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803834/
With a deeper understanding of the structural principles and functional signals of cytokine-receptor interactions, artificial modification of cytokine signaling through protein engineering and synthetic immunology has become an increasingly feasible and powerful approach. Engineered cytokines are designed to selectively target cells. Herein, the theoretical and experimental evidence of cytokine engineering is reviewed, and the “supercytokines” resulting from structural enhancement and the “immunocytokines” generated by antibody fusion are described. Finally, the “engager cytokines” formed by the crosslinking of cytokines and bispecific immune engagers and other synthetic cytokines formed by nonnatural analogs are also discussed.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803834/
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