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Not sure if I understand your question, but if you take a drug whose patent is expired which may be available as a generic, and you combine that drug with one that is still patented, the combo drug gets a whole new patent.

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Two seperate drugs when used together do not gain a new patent. They are each under their own seperate patents and are bound to their seperate expiration dates. A new patent is issued only when there is substantial modification. For example, there is leronlimab's original patent but they were able to gain a new patent for the concentrated version.