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Could you name one or two other drugs having having had floodgates of opportunities come to fruition? Be nice to research such drugs and their pathways to success

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Penicillin. Its pathway to success was through an open window; some mold floated through the window and landed on Fleming's microscope slide. He did the most amazing thing: instead of cursing and throwing out the slide, he moved it under his microscope and watched closely... and as he watched, this intruder, this foreign substance, began to destroy bacteria.