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I posted a theory back in 2019 that leronlimab could possibly cure HIV in the very long term (approximately 15 years). I surmised a slow elimination of HIV reservoirs as virus reproduction continued to drop that could be enhanced by drugs that helped push the virus out of the reservoirs. Maraviroc and by association leronlimab also helps eliminate those reservoirs and strengthens the immune systems ability to fight the virus. It has been shown that leronlimab would increase natural killer T-cells. That seems to be what is happening here but at a very accelerated pace.

Stem cell transplantation from regular CCR5 expressing donors for HIV patients does not affect a cure. The difference here is that the lowered CCR5 expression from a single allele donor means that there is less viral reproduction, the destruction of existing reservoirs and less of a chance for the virus to create new reservoirs and for it to destroy the immune system. Leronlimab does all that except destroying existing reservoirs thus the long period of time it would take for a possible cure.

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The second Berlin patient proves that an HIV cure is possible despite a functioning docking site for the virus. "This means that the cure is probably not due to the genetic CCR5 equipment of the stem cell donor, but rather to the fact that the transplanted immune cells of the donor eliminated all of the patient's HIV-infected cells," explains Christian Gaebler. "By replacing the immune system, we have apparently destroyed all of the virus's hiding places, so that the HIV virus could no longer infect the donated, new immune cells."

It is still unclear why the stem cell transplant led to a cure in this case, while the virus multiplied again in comparable cases. The researchers are considering several potential factors. "The speed with which the new immune system replaces the old one may have an influence," says Christian Gaebler. "In the second Berlin patient, this was completed relatively quickly, in less than 30 days. But perhaps the donor's immune system also has special properties, such as particularly active natural killer cells, which ensure that even low levels of HIV activity are recognized and eliminated."

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https://www.charite.de/service/pressemitteilu...r_patient/

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