I may not be reading the abstract right. Yes, two monkeys still had undetectable SHIV 70 weeks later. And yes, a third (of the four) monkeys started to make Leron on its own and has undetectable SHIV RNA a year later. But even the fourth monkey's story -- which sounds like the title of my next novel -- sounds pretty good, doesn't it? It also has detectable plasma Leron and declined plasma viremia.

So all four of the monkeys had good results, right? As in 100%?

Here's the part of the abstract about the two monkeys who developed anti-drug antibodies:

Quote:

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The remaining two RMs developed ADAs within 5-15 weeks post-AAV resulting in complete clearance of Leronlimab from plasma as well as a rapid decline in CCR5 RO. Spontaneous reemergence of CCR5 RO by Leronlimab was observed approximately 1 year post-AAV. One of the two animals has had full and sustained CCR5 RO, detectable plasma Leronlimab, and undetectable SHIV RNA in plasma for over 1 year post-reexpression. The second re-expressing animal has achieved and maintained 100% CCR5 RO for about 10 weeks, has detectable plasma Leronlimab, and has declined plasma viremia.

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