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Posted On: 06/30/2024 9:33:29 AM
Post# of 154119
Re: Nt2innvovate #144810
Quote:
Being chronically hyperthyroid has negative clinical effects also (Graves disease) and does resmetiron avoid this?
They tried general T3 analogues in NASH with bad side effects, especially heart problems. Several companies including Madrigal went to thyroid hormone receptor beta specific T3s because THRb is preferentially expressed in the liver and is less common in the heart.
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