Here’s a clue or two.

“In conclusion NK cells in PBC are sensitive to minute quantities of IL-12 and have a “primed” phenotype. We therefore propose that peripheral priming of NK cells to express tissue-homing markers may contribute to the pathophysiology of PBC.“

https://www.frontiersin.org/journals/immunolo...02633/full

This is from 2001, and discussing T Cells not NK, but I see a pathway.

“However, these TCR-triggered T cells expressed much higher levels of CCR5 when stimulated with IL-12. Although IL-2 also induced CCR5 expression, CCR5 expression was more potent in IL-12 than IL-2 stimulation. These results indicate that, in addition to IL-2, IL-12 plays an important role in the induction of CCR5 expression on T cells, particularly TCR-triggered T cells.”

IL-12 as well as IL-2 upregulates CCR5 expression on T cell receptor-triggered human CD4+ and CD8+ T cells
Y F Yang et al. J Clin Immunol. 2001 Mar.

https://pubmed.ncbi.nlm.nih.gov/11332650/

If IL-12 unregulates CCR5 in T cells, we can occupy those little fritters. Not sure if IL-12 produces CCR5s on NKs.

Thanks though. Fun to noodle on.