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Posted On: 06/05/2024 9:11:38 AM
Post# of 155869
Footnote: per this abstract from the Journal of Clinical Oncology involving a pooled analysis it is mentioned (N=28) that 17 of the patients had metastasis, 7 involving the brain.
https://ascopubs.org/doi/10.1200/JCO.2022.40.16_suppl.e13062
The murine glioblastoma study at Montefiore will obviously be of great interest. I have a recollection from that Leronlimab has demonstrated 70% CCR5 receptor occupancy in the brain, so we can infer it does cross the blood brain barrier. Knowing the central role this receptor plays in some cancers (VEG-F inhibitor etc…) I am optimistic but we will have to wait till this plays out in a clinical trial…the mice will have the first word.
https://ascopubs.org/doi/10.1200/JCO.2022.40.16_suppl.e13062
The murine glioblastoma study at Montefiore will obviously be of great interest. I have a recollection from that Leronlimab has demonstrated 70% CCR5 receptor occupancy in the brain, so we can infer it does cross the blood brain barrier. Knowing the central role this receptor plays in some cancers (VEG-F inhibitor etc…) I am optimistic but we will have to wait till this plays out in a clinical trial…the mice will have the first word.
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