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Posted On: 06/04/2024 12:08:14 PM
Post# of 148870
No, VIR is developing broadly neutralizing antibodies:
They are developing antibodies to attack and destroy HIV.
We are preventing HIV cell entry into immune cells by blocking CCR5. (Really we are trying to prevent our newly transplanted immune cells from being infected by residual HIV, thus allowing them to seek out and destroy the HIV / eradicate it from the body).
Why not a combination of bnABs, CCR5 blockers, plus either gene edited HSPCs or HSPC transplantation (from CCR5- - donor) for a cure?
Cytodyn is going to try HSPC transplantation with CCR5 blockers. Not sure if we will require that donors be CCR5- homozygous or not.
Quote:
Cure
To bring hope to the millions of people living with HIV, we are developing a cocktail of broadly neutralizing antibodies (bnAbs) that have been engineered to enhance T-cell responses. Given the diversity of HIV strains worldwide and the virus’ history of generating viral resistance, we believe a combination of at least two bnAbs is required to achieve a functional cure.
They are developing antibodies to attack and destroy HIV.
We are preventing HIV cell entry into immune cells by blocking CCR5. (Really we are trying to prevent our newly transplanted immune cells from being infected by residual HIV, thus allowing them to seek out and destroy the HIV / eradicate it from the body).
Why not a combination of bnABs, CCR5 blockers, plus either gene edited HSPCs or HSPC transplantation (from CCR5- - donor) for a cure?
Cytodyn is going to try HSPC transplantation with CCR5 blockers. Not sure if we will require that donors be CCR5- homozygous or not.
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