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I wonder if insulin resistance may explain Covid triggering diabetes 2 in some patients.

HDL is the good cholesterol. I think Ohm showed a link between CcR5 blockade and lowering bad cholesterol. LDL. I wonder if we could impact this reduction in HDL also.

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Blockading CCR5 can reduce insulin resistance and increase insulin production. That lowered HDL and higher LDL is certainly caused by inflammation which leronlimab would reduce.

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And then ferroptosis. Some in my family have high iron in blood (hemochromatosis). I do not. But my brother just had his second hip replaced at 60 possibly attributable to high iron. It also leads to organ, tissue, bone issues later in life.

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Ferritin is increased due to inflammation and high levels of ferritin also increase inflammatory cytokines in a feedback loop. In Long Covid leronlimab would reduce that ferritin. If the ferroptosis is driven by inflammation or genetic variation that causes inflammation the leronlimab would help. If the genetic variation directly affects ferritin production then leronlimab may be of some help by stopping the feedback loop.