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First, with age, more CCR5 receptors appear to form in the brain. This could be because of an increase in inflammation throughout the body that tends to occur with our immune histories. No doubt, older people have immune systems that are pulled further away from homeostasis.

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A likely cause is that as people age mitochondrial dysfunction and genetic faults increase affecting new cell growth. That instability could increase levels of CCR5 and thus inflammation. CCR5 blockade can help mitochondrial dysfunction and there's even a possibility it could help with genetic faults given that it can stop damaged DNA repair from chemotherapy.