Yes, we need a massive courageous billboard.

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Clearance of dying cells is fundamental to homeostasis, tissue repair and disease5. Efferocytosis, the engulfment of dead cells by phagocytes, is performed predominantly by macrophages6. Macrophages are critical immune cells and are highly plastic, acquiring tumor repressive or supportive functions depending on the context7,8. PDAC liver metastasis is accompanied by macrophage accumulation9,10, with macrophages often displaying an immunosuppressive phenotype, promoting tumor growth and limiting the impact of immunotherapy11,12,13

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This disease process in the pancreas sounds all too familiar in comparison to the process when considering MASH and liver fibrosis.

NASH Pathogenesis