I think if the release of HIV from reservoirs occurs, say, due to a challenge, then, the immune system would be right on that HIV and upregulate the manufacture of new immune cells like CD4 and CD8 T lymphocytes and that in turn would upregulate the increased manufacture of leronlimab necessary to compensate for the increased work load. This would sort of work out to a self-regulated dosing based on level of Immune Activation.