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Yes, in all these organs and systems, scarring would reduce their capacity to perform their work. The organ would scar and as a result, its output would be reduced, whereas in the liver, it regenerates and scars and its output remains relatively the same, but with MASH, liver enzymes climb pointing to how sick it is.

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In MASH whether related to HIV or without the output does not remain the same the scarring severely damages the liver and any regeneration only partially recovers that damage. Fibrosis related to HIV is MASH.

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Do you think it is a good idea to span the output of the equation to go from say (-25 -10 0 10 25) where values from -10 to +10 would be considered "normal healthy patients". Values from + 10 to +25 would be considered "Pre-Inflammatory". Values from -10 to -25 would be considered "Pre-Proliferative". Values in excess of +25 would be considered Inflammatory and values less than -25 would be considered Proliferative.

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A cumulative total score rather than a generalized score would be more precise and it would be easier to show statistical significance.