2x New MANF that G posted below. Obviously still waiting for Jan 5 for Magna update. More important than ever as it looks like Todos got no new investment and it's future is extremely in doubt.

1. Mesencephalic astrocyte-derived neurotrophic factor (MANF) alleviates cerebral ischemia/reperfusion injury in mice by regulating microglia polarization via A20/NF-κB pathway
from China Pharmaceutical University,

"The results showed that MANF decreased brain infarct volume, neurological scores, and brain water content. In addition, MANF promoted the polarization of microglia to an anti-inflammatory phenotype both in vivo and in vitro, which are related to A20/NF-κB pathway. In summary, MANF may offer novel therapeutic approaches for ischemic stroke in the process of microglia polarization."

https://www.sciencedirect.com/science/article...692301723X

2. Deletion of mesencephalic astrocyte-derived neurotrophic factor delays and damages the development of white pulp in spleen
from Anhui Provincial Children’s Hospital, in Immunobiology Volume 229, Issue 1, January 2024, 152778

"we found that MANF deficiency inhibited white pulp development in MANF knockout mice, thus indicating that MANF played an important role in the white pulp development of rodent spleen tissues."

https://www.sciencedirect.com/science/article...8523045801