(Total Views: 619)
Posted On: 12/29/2023 9:22:11 AM
Post# of 155178
"immunosupressive cells...research unveiled the pivotal role of the CCL5/CCR5 axis in orchestrating the chemotactic recruitment of G-MDSCs within the tumor microenvironment, a process that is enhanced by miR-9. These findings provide fresh insights into the molecular mechanisms governing the accumulation of MDSCs (Myleoid Derived Suppressive Cells)within the framework of breast cancer development.
"Furthermore, SOCS2 and SOCS3 were identified as direct targets of miR-9, and we confirmed that miR-9 recruited G-MDSCs by activating the CCL5/CCR5 signaling axis. Overall, our results suggest that miR-9 can promote chemotactic enrichment of G-MDSCs in tumors through the SOCS3/CCL5/CCR5 signaling axis, thereby promoting breast cancer proliferation.
https://pubmed.ncbi.nlm.nih.gov/38145323/
ccr5 everywhere
LL everywhere
"Furthermore, SOCS2 and SOCS3 were identified as direct targets of miR-9, and we confirmed that miR-9 recruited G-MDSCs by activating the CCL5/CCR5 signaling axis. Overall, our results suggest that miR-9 can promote chemotactic enrichment of G-MDSCs in tumors through the SOCS3/CCL5/CCR5 signaling axis, thereby promoting breast cancer proliferation.
https://pubmed.ncbi.nlm.nih.gov/38145323/
ccr5 everywhere
LL everywhere
(11)
(1)
