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When I mention LL to my friend who was designing the Pandemic Quick Response for the DOD, he called it "voodoo" medicine in April 2020.

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Because he was not well versed in the CCR5 receptor.

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Any sufficiently advanced technology is indistinguishable from magic. - Arthur C. Clarke

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I first looked at leronlimab for HIV in 2019. The mechanism of action for that was obvious. I was initially skeptical about it for other indications until I went into a very deep dive into what pathways CCR5 controls.