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Additionally, a substantial amount of preclinical trials highlight the potential of diet, fecal microbiota transplantations, as well as pre- and probiotics in modulating the brain’s serotonergic neurotransmitter system

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An overactive immune system and inflammation can cause the death of good gut bacteria.

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preceded by neurotoxic amyloid-beta (Aβ) plaque aggregation extraneuronally, and, intraneuronally deposited neurofibrillary tangles (NFT) of phosphorylated tau (P-tau), both being histological hallmarks of AD

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Both decreased when CCR5 is blocked.

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Other factors are suspected to be equally involved, such as a blood-brain barrier disintegrity, oxidative stress and mitochondrial dysfunction

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Also fixed by CCR5 blocking.

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Furthermore, a substantial amount of evidence suggests that neuroinflammation plays a contributing role in AD development by accelerating the abovementioned processes
https://www.sciencedirect.com/science/article...3721003032

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