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Posted On: 10/25/2023 4:36:56 PM
Post# of 148892
ohm20 wrote:
A recent preprint discusses LC, aka PASC, and inflammation in the brain. There are some PET images which show this. Here is an excerpt from the abstract.
The COVID-19 pandemic caused by SARS-CoV-2 has triggered a consequential public health crisis of post-acute sequelae of COVID-19 (PASC), sometimes referred to as long COVID. The mechanisms of the heterogeneous persistent symptoms and signs that comprise PASC are under investigation, and several studies have pointed to the central nervous and vascular systems as being potential sites of dysfunction. In the current study, we recruited individuals with PASC with diverse symptoms, and examined the relationship between neuroinflammation and circulating markers of vascular dysfunction. We used PBR28 PET neuroimaging, a marker of neuroinflammation, to compare 12 PASC individuals versus 43 normative healthy controls. We found significantly increased neuroinflammation in PASC versus controls across a wide swath of brain regions including midcingulate and anterior cingulate cortex, corpus callosum, thalamus, basal ganglia, and at the boundaries of ventricles. We also collected and analyzed peripheral blood plasma from the PASC individuals and found significant positive correlations between neuroinflammation and several circulating analytes related to vascular dysfunction. These results suggest that an interaction between neuroinflammation and vascular health may contribute to common symptoms of PASC.
If anyone wants to read the entire article or see the PET scans, you can do so at this link.
https://www.biorxiv.org/content/10.1101/2023....117v1.full
Ohm, do you see any new, noteworthy items in this preprint? Is this further proof that Leronlimab will likely be beneficial for Alzheimer's?
What a horrible disease. I feel certain that all of us know someone who has suffered from this. Perhaps one day LL will be approved for Alzheimer's and we can look back with pride to the days when we were among the few who had enough faith in LL to buy CYDY.
Quote:
There is a correlation between chronic inflammation and Alzheimer's.. That inflammation can be triggered by injury or disease. Lessen the chance of either occurring and you lessen the incidence of Alzheimer's. Of course leronlimab can knock down inflammatory activity once it does occur.
A recent preprint discusses LC, aka PASC, and inflammation in the brain. There are some PET images which show this. Here is an excerpt from the abstract.
The COVID-19 pandemic caused by SARS-CoV-2 has triggered a consequential public health crisis of post-acute sequelae of COVID-19 (PASC), sometimes referred to as long COVID. The mechanisms of the heterogeneous persistent symptoms and signs that comprise PASC are under investigation, and several studies have pointed to the central nervous and vascular systems as being potential sites of dysfunction. In the current study, we recruited individuals with PASC with diverse symptoms, and examined the relationship between neuroinflammation and circulating markers of vascular dysfunction. We used PBR28 PET neuroimaging, a marker of neuroinflammation, to compare 12 PASC individuals versus 43 normative healthy controls. We found significantly increased neuroinflammation in PASC versus controls across a wide swath of brain regions including midcingulate and anterior cingulate cortex, corpus callosum, thalamus, basal ganglia, and at the boundaries of ventricles. We also collected and analyzed peripheral blood plasma from the PASC individuals and found significant positive correlations between neuroinflammation and several circulating analytes related to vascular dysfunction. These results suggest that an interaction between neuroinflammation and vascular health may contribute to common symptoms of PASC.
If anyone wants to read the entire article or see the PET scans, you can do so at this link.
https://www.biorxiv.org/content/10.1101/2023....117v1.full
Ohm, do you see any new, noteworthy items in this preprint? Is this further proof that Leronlimab will likely be beneficial for Alzheimer's?
What a horrible disease. I feel certain that all of us know someone who has suffered from this. Perhaps one day LL will be approved for Alzheimer's and we can look back with pride to the days when we were among the few who had enough faith in LL to buy CYDY.
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