Another HIV patient cured after stem cell treatment. What do they think was involved in this?
Surprise! CCR5 discussion.

Quote:

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In all five prior cases of durable HIV remission reported after receiving stem cell transplants, the donors had a mutation that knocks out the receptor CCR5 that HIV needs to enter a cell, the CCR5 Delta 32 mutation, she noted at a press conference.

"In this case, the donor did not have a CCR5 deletion. He received a transplant from a donor who had normal wild-type stem cells, meaning that those cells were susceptible to HIV infection," she said.

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The prior potential HIV "cure" cases after stem cell transplant include:

Timothy Brown, the initial "Berlin patient" who sparked hopes of a cure, who died 12 years after the transplant due to recurrence of cancer
Adam Castillejo, the "London patient," who has been off antiretroviral therapy for 5 years
Marc Franke, the "Dusseldorf" patient, who has been off antiretroviral therapy for 4 years
An unidentified New York patient off antiretroviral therapy for 2.5 years
Paul Edmonds, the "City of Hope (California)" patient, who has been off antiretroviral therapy for 2 years since his transplant

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https://www.medpagetoday.com/meetingcoverage/...ate_active