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Posted On: 07/01/2023 2:23:57 AM
Post# of 154039
From the discussion part:
"In conclusion, by applying a novel high-throughput functional genomics approach, we have shown that genetic factors regulate immune responses in T1D patients. We show genetic susceptibility to immune phenotypes in patients with T1D and highlight the importance of T cell immunity in the genetic regulation of T1D. We also identify specific cell populations (CCR5+ Tregs) that are likely involved in pathophysiology of T1D. Together, these findings may provide an avenue toward identifi-
cation of novel PREVENTIVE and THERAPEUTIC treatments."
"In conclusion, by applying a novel high-throughput functional genomics approach, we have shown that genetic factors regulate immune responses in T1D patients. We show genetic susceptibility to immune phenotypes in patients with T1D and highlight the importance of T cell immunity in the genetic regulation of T1D. We also identify specific cell populations (CCR5+ Tregs) that are likely involved in pathophysiology of T1D. Together, these findings may provide an avenue toward identifi-
cation of novel PREVENTIVE and THERAPEUTIC treatments."
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