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Posted On: 06/27/2023 1:52:44 PM
Post# of 153968
I had ChatGPT make this a little more readable -
"In pre-manifesting Huntington's disease (HD) and tauopathy mouse models, there is an increase in the levels of a protein called CCR5 and its chemical messengers. This increase in CCR5 may be due to a process that keeps building up CCR5 because it is not properly broken down.
When a specific pathway related to CCR5 is blocked, either through medication or genetic manipulation, it improves the dysfunction of another cellular process called mTORC1-autophagy and reduces the damage to the brain in these mouse models.
This suggests that CCR5 hyperactivity plays a role in driving the progression of these diseases."
"In pre-manifesting Huntington's disease (HD) and tauopathy mouse models, there is an increase in the levels of a protein called CCR5 and its chemical messengers. This increase in CCR5 may be due to a process that keeps building up CCR5 because it is not properly broken down.
When a specific pathway related to CCR5 is blocked, either through medication or genetic manipulation, it improves the dysfunction of another cellular process called mTORC1-autophagy and reduces the damage to the brain in these mouse models.
This suggests that CCR5 hyperactivity plays a role in driving the progression of these diseases."
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