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Posted On: 06/26/2023 9:53:41 PM
Post# of 148884
Apologies if this has been posted previously (may have been available as pre-publication proof), but further compelling argument for the use of leronlimab in neurodegenation.
"Microglial cytokines poison neuronal autophagy via CCR5, a druggable target"
https://www.tandfonline.com/doi/full/10.1080/...23.2221921
"pharmacological, or genetic inhibition of CCR5 rescues mTORC1-autophagy dysfunction and improves neurodegeneration in HD and tauopathy mouse models, suggesting that CCR5 hyperactivation is a pathogenic signal driving the progression of these diseases."
"Microglial cytokines poison neuronal autophagy via CCR5, a druggable target"
https://www.tandfonline.com/doi/full/10.1080/...23.2221921
"pharmacological, or genetic inhibition of CCR5 rescues mTORC1-autophagy dysfunction and improves neurodegeneration in HD and tauopathy mouse models, suggesting that CCR5 hyperactivation is a pathogenic signal driving the progression of these diseases."
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