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Posted On: 06/26/2023 2:43:46 PM
Post# of 151796
We know that inflammatory processes driven by CCR5 breaks down the blood brain barrier. Specific mention of what she found (claudin-5) shown in this study. Leronlimab would downregulate both TGF-b and MMP-9 reducing blood brain barrier degradation.
Quote:
TGFβ1 exacerbates blood–brain barrier permeability in a mouse model of hepatic encephalopathy via upregulation of MMP9 and downregulation of claudin-5
https://www.nature.com/articles/labinvest201570
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