Excerpt: "CCR5 and CCL5 are important in the targeting of immune cells by HIV. This is the first study providing valuable hints that both CCR5 and CCL5 might also serve as markers of therapy response prediction in MDD. Regarding neurocognitive impairment in depression, CCR5 and CCL5 did not reveal characteristic changes upon MDD treatment such as executive functions, which are probably delayed. However, changes of emotional perception appear to be an earlier responding feature.


Major depressive disorder (MDD) is a highly prevalent and disabling disorder that is expected to become the largest global burden of disease within the next 2 decades according to the World Health Organization [1]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006585/