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Posted On: 01/25/2023 9:17:38 AM
Post# of 148878
Riz , my understanding of the science may not be much better, but our effect on other chemokibes may hold the answer. If indeed, we have use in MS it may be the anti-inflammatory and immune modulating effects LL has across the immune system - rebalancing the CD4/CD8 ratio, for instance.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156228/
“Although most research on the pathogenesis of MS has focused on the role of CD4 T cells, in fact, compared to most animal models, the main T cells found in the central nervous system of MS patients are CD8 T cells, suggesting that CD8 T Cells may play an important role in human disease [52]. There is growing evidence indicates that successful treatments are often related to changes in many other lymphocyte subpopulations, including B cells, NK cells, Lti cells, other ILC cells, γδT cells, NKT cells, MAIT cells and innate B cells. These findings not only indicate that multiple lymphocyte subpopulations are involved in the pathogenesis of the disease, but also identify the cells as potential targets for immunotherapy [117].”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156228/
“Although most research on the pathogenesis of MS has focused on the role of CD4 T cells, in fact, compared to most animal models, the main T cells found in the central nervous system of MS patients are CD8 T cells, suggesting that CD8 T Cells may play an important role in human disease [52]. There is growing evidence indicates that successful treatments are often related to changes in many other lymphocyte subpopulations, including B cells, NK cells, Lti cells, other ILC cells, γδT cells, NKT cells, MAIT cells and innate B cells. These findings not only indicate that multiple lymphocyte subpopulations are involved in the pathogenesis of the disease, but also identify the cells as potential targets for immunotherapy [117].”
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