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Posted On: 12/17/2022 10:46:29 PM
Post# of 148903
Hey kabonk,
Merry Christmas and Happy Holidays.
It’s interesting to me Stiff Persons Disease has come around again as rare as it may be. I’d love to know how your patient diagnosis turned out. Hope it helped. PM me if you need to.
“Nice find. This coincidence is hard to believe, but my neuromuscular neurology colleague and I are this week working on a neurodiagnostic testing protocol for stiff person's syndrome, as we just saw such a patient two weeks ago. Many SPS patients have anti-GAD or autoimmunity against GABA receptor associated proteins.
I was telling him about CAR-TRegs and destroying specific population of auto antigen producing B cells only, but other immunomodulatory drugs could help too. Will take a look at the tocilizumab and Covid paper. I wonder if it was Covid and not tocilizumab that led to regression of SPS symptoms?
I'm still trying to wrap my head around how LL can work to suppress autoimmunity in say GVHD and perhaps something like SPS, yet also increase natural immunity in cancer”
By the way, your last sentence that I quoted was the most interesting question posted on this sight in my opinion last year, or this. I think the answer lies in the ability of LL fulfilling the CCR5 receptor in such a way that allows further chemotaxis by the usual immune system’s ligands. But what do I know? I’m still trying to wrap my head around it too.
Read More: https://investorshangout.com/post/newpost/605...z7nmzvKn9h
Merry Christmas and Happy Holidays.
It’s interesting to me Stiff Persons Disease has come around again as rare as it may be. I’d love to know how your patient diagnosis turned out. Hope it helped. PM me if you need to.
“Nice find. This coincidence is hard to believe, but my neuromuscular neurology colleague and I are this week working on a neurodiagnostic testing protocol for stiff person's syndrome, as we just saw such a patient two weeks ago. Many SPS patients have anti-GAD or autoimmunity against GABA receptor associated proteins.
I was telling him about CAR-TRegs and destroying specific population of auto antigen producing B cells only, but other immunomodulatory drugs could help too. Will take a look at the tocilizumab and Covid paper. I wonder if it was Covid and not tocilizumab that led to regression of SPS symptoms?
I'm still trying to wrap my head around how LL can work to suppress autoimmunity in say GVHD and perhaps something like SPS, yet also increase natural immunity in cancer”
By the way, your last sentence that I quoted was the most interesting question posted on this sight in my opinion last year, or this. I think the answer lies in the ability of LL fulfilling the CCR5 receptor in such a way that allows further chemotaxis by the usual immune system’s ligands. But what do I know? I’m still trying to wrap my head around it too.
Read More: https://investorshangout.com/post/newpost/605...z7nmzvKn9h
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