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Posted On: 12/13/2022 5:46:42 AM
Post# of 154850
Quote:
And you see that arrow , and that leads to release of this chemokine CCL2 or MCP-1 . Once this is released, this is the bloodstream here on the top. What you see is these inflammatory cells, mainly circulating monocytes , start being recruited . And those are CCR2
That part of the CC had me shaking my head. CCL2 also binds to CCR5 and with the greater preponderance of CCR5 over CCR2 leronlimab would also effect the cascade at that point and not only starting at the myofibroblast stage. Later in the CC there's even a slide that shows the downregulation of CCL2 by leronlimab.
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